אבקת Pregabalin

Pregabalin Powder Video-AAsraw

דמויות בסיסיות

מה Pregabalin pבעל?

Pregabalin is a medication used to relieve neuropathic pain, including pain from diabetic nerve damage in the arms, hands, legs, feet, or toes, as well as postherpetic neuralgia (pain after shingles). It is also used to treat fibromyalgia, neuropathic pain after a spinal cord injury, and as an adjuvant treatment for some types of seizures in both adults and children. Furthermore, pregabalin is an anticonvulsant medicine that works by lowering pain signals from injured nerves. It was first approved in 2004 for the treatment of epilepsy, but it also affects brain chemicals involved in pain signaling.

How does pregabalin works on the body?

Pregabalin is a flexible medication that can treat a variety of medical concerns. It can inhibit pain signals in neuropathic pain, regulate neurotransmitter release to avoid seizures, and can assist decrease anxiety by controlling neurotransmitter release.

Block or suppress pain signals:

Neuralgia, also known as neuropathic pain, is frequently caused by nerve injury, which results in aberrant pain signals. Pregabalin disrupts this process by blocking or suppressing pain messages, primarily in the brain and spinal cord, where they are processed and relayed to the rest of the body. Pregabalin can help people with illnesses such as diabetic neuropathy, post-herpetic neuralgia, and fibromyalgia relieve persistent and frequently excruciating pain by slowing the transmission of pain signals.

Modulates abnormal electrical activity in the brain:

Epilepsy is characterized by abnormal and excessive electrical activity in the brain, leading to seizures. Pregabalin works by regulating aberrant electrical activity in the brain to control epileptic seizures. Pregabalin decreases the excitability of brain neurons, which reduces the risk of aberrant discharges. Pregabalin can help people with epilepsy better regulate their condition and lessen the frequency and severity of seizures by regulating the electrical activity in the brain.

Stabilizes neurotransmitter systems:

Anxiety disorders are caused by a chemical imbalance in the brain, which causes emotions of unease, anxiety, and fear. Pregabalin’s sedative effects are mediated via these neurotransmitter systems. Pregabalin, in particular, suppresses the release of specific brain chemicals that produce anxiety. Although pregabalin is not usually used as a first-line treatment for anxiety disorders, it may be used in some cases where other medications have been demonstrated to be less effective.

Although pregabalin powder is widely available worldwide, it is important to exercise caution when considering buying it and only buy it from reputable sources. Many pregabalin manufacturers and suppliers claim they supply pregabalin of high quality, but not all the pregabalin powder is authentic. Purchasing medications from unverified sources or online marketplaces can be risky and may result in receiving counterfeit or substandard products.

הבenefits of אבקת Pregabalin 

Pregabalin powder is a flexible drug that can help people with a variety of medical issues. Diabetic peripheral neuropathy, postherpetic neuralgia, partial epilepsy, fibromyalgia, neuropathic pain, and generalized anxiety disorder are some of the most frequent illnesses that can benefit by the use of AASraw pregabalin powder.

①נוירופתיה היקפית סוכרתית (DPN)

Diabetic peripheral neuropathy (DPN) is a common side effect of both type 1 and type 2 diabetes that affects 30-40% of patients. Pain, weakness, and loss of sensation are symptoms of this nerve disorder in the hands and feet. Pregabalin powder is the first-line treatment for DPN, and it provides substantial pain relief.

②Neuralgia Postherpetic (PHN)

Postherpetic neuralgia (PHN) is a crippling chronic pain disease that can occur following a herpes zoster outbreak and grows more common as patients get older. PHN is difficult to treat and frequently requires the use of many medications to provide effective pain relief. The most recent medicine licensed for PHN is pregabalin powder. Data show efficacy in pain relief and sleep disruption caused by PHN in affected patients.

③אפילפסיה חלקית

Pregabalin powder is an antiepileptic medication that has been approved and sold for use as a supplementary treatment for partial epilepsy. It modulates neurotransmitter release in the CNS by acting on presynaptic calcium channels. Three multi-center randomized, double-blind, placebo-controlled trials involving patients with refractory partial epilepsy found that pregabalin had an antiepileptic effect when compared to placebo as supplementary therapy, with 31-51% of patients experiencing a 50% reduction in seizure frequency.

④פיברומיאלגיה

Pregabalin powder is believed to relieve fibromyalgia pain by restricting sensory propagation of nociception and neurotransmitter release in the ascending pain pathway via calcium channel blockage. Pregabalin has also been shown to reduce glutamate and glutamine levels in fibromyalgia patients’ posterior insula, interfering with its functional connection to the default mode network.

Occipital nerve stimulation (ONS) investigations on fibromyalgia patients show that conditioned pain regulation is reduced. Pregabalin has been shown in nerve-injured rats to have effects on descending pain circuitry; consequently, pregabalin’s central actions may contribute to its success in treating fibromyalgia.

</s>כאב נוירופתי

Pregabalin podwer is a voltage-gated Ca2+ channel antagonist that has analgesic effects by binding selectively to the alpha-2-delta subunit. It efficiently treats the symptoms of many different types of neuropathic pain and has evolved into a first-line therapeutic drug with a high level of safety and efficacy. It has been shown to be effective in the treatment of symptoms such as allodynia and hyperalgesia in preclinical study in several animal models of neuropathic pain.

 </s>הפרעת חרדה כללית (GAD)

Pregabalin has been found in studies to be consistently effective in the treatment of generalized anxiety disorder (GAD). A critical evaluation found that seven out of eight randomized and controlled trials with pregabalin powder doses ranging from 150 to 600mg indicated statistically significant reductions in Hamilton Anxiety Rating Scale scores. The incidence of withdrawal symptoms and rebound anxiety after discontinuation was minimal in a separate research involving GAD patients who had pregabalin powder therapy for 12-24 weeks. Pregabalin powder can also be an effective treatment choice for GAD patients who have not reacted well to antidepressant medication.

Notice: Because the actual efficacy of pregabalin is tied to the quality of the product, it is critical to get high-quality pregabalin powder from a reliable pregabalin powder supplier. AASraw manufactures and supplies pregabalin raw powder in accordance with strict manufacturing requirements. If you need it, AASraw’s pregabalin powder is an excellent option.

What are the side effects of Pregabalin?

The side effects of pregabalin powder are similar to those of other central nervous system depressants. Adverse drug reactions related to the use of pregabalin include:

Very common (>10%):

סְחַרחוֹרֶת

נוּמָה

נפוץ (1-10%):

ראייה מטושטשת

כֶּפֶל רְאִיָה

הַרגָשָׁה טוֹבָה

בִּלבּוּל

תיאבון מוגבר ועלייה במשקל לאחר מכן

Uncommon (0. 1-1%):

היפוגליקמיה

פריחה

התכווצויות שרירים

מיאלגיה

ארתרלגיה

טרומבוציטופניה

אבנים בכליות

זהירות: אם תופעות הלוואי אינן פוחתות או נעלמות בהדרגה, פנה מיד לטיפול רפואי. חוץ מזה, אנא הקפד לקנות מוצרים מוסמכים כדי להפחית תופעות לוואי.

Dosage and administration of Pregabalin powder for reference

The following table shows the suggested dosage of pregabalin powder for various medical conditions for reference:

Precaution: It should be noted that these dosages are only suggestions and may vary depending on individual characteristics such as age, weight, and medical history. Furthermore, the dosage may need to be changed over time based on the individual’s response to the medication and any side effects. To establish the optimum dosage for each unique medical condition, contact with a healthcare specialist.

Where to buy Pregabalin powder?

There are numerous internet shops and suppliers who sell peptides and associated items. Pregabalin may be available for purchase on these websites. When making an online purchase, it is critical to select a recognized and trustworthy vendor. Read user reviews, look for certifications, and confirm the product’s validity and quality.

AASRA is a respected and competent manufacturer and supplier specializing in the supply of pregabalin powder. With our industry expertise and experience, we provide high-quality products to researchers, pharmaceutical companies, and individuals working in pregabalin synthesis and development. If you are looking for a dependable pregabalin supplier, AASraw is a fantastic option.

שאלות נפוצות

Is pregabalin a powerful pain reliever?

Pain was reduced by a third or more for 5 out of 10 people who took pregabalin 300 mg or 600 mg daily, compared to 3 out of 10 who took placebo. Pregabalin 300 mg or 600 mg daily reduced pain by 50% or more in 3 or 4 out of 10 persons with diabetes pain, and 2 or 3 out of 10 with placebo.

Does pregabalin interfere with sleep?

Pregabalin is effective and safe in the treatment of sleep disturbances in fibromyalgia patients since it reduces the number of awakenings while increasing sleep length.

How long may pregabalin be taken safely?

For how long should I take pregabalin? Pregabalin will need to be used for as long as you require nerve pain alleviation. It should be examined every six to twelve months. If someone has been taking pregabalin for a long time, it may no longer work as well or be necessary.

When is the optimum time to take pregabalin?

It is best to take the first dose at night. The typical pain management target dose is 300-450 mg/day (e.g., 150 mg twice or three times each day). Pregabalin’s maximum daily dose is 600 mg. It is safe to take with or without food.

Is pregabalin toxic to the liver?

Pregabalin is a neuronal activity inhibitor that is used to treat painful neuropathy and as an anticonvulsant. Serum aminotransferase increases are not related with pregabalin therapy, and clinically obvious liver impairment from pregabalin has been documented but appears to be fairly rare.

Is pregabalin associated with bone loss?

Akin and colleagues discovered that administering pregabalin (Lyrica) in its pharmacological composition for six months had no effect on bone metabolism, regardless of gender, in a study of 40 patients, 27 women and 13 males.

איך לקנות pregabalin powder from AASraw?

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❺סחורה שהתקבלה ותן הערות.

אבקת פרגבלין (148553-50-8)-COA

אבקת פרגבלין (148553-50-8)-COA

מחבר מאמר זה:
ד"ר מוניק הונג סיים את לימודיו בפקולטה לרפואה ב-UK Imperial College בלונדון

מחבר מאמר כתב עת מדעי:
1. אלכסנדרה מ' שטיין
המחלקה לאורטופדיה, Hôpital Cochin Paris, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France
2. טומויה אקשי
הפקולטה לרוקחות, אוניברסיטת Keio, 1-5-30 Shibakoen, Minato-ku, טוקיו 105-8512, יפן
3. HR Martínez
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey NL, מקסיקו
4. מרקוס דולד
4. המחלקה לפסיכיאטריה ופסיכותרפיה, האוניברסיטה הרפואית של וינה, וינה, אוסטריה
בשום אופן אין רופא/מדען זה מאשר או תומך ברכישה, מכירה או שימוש במוצר זה מכל סיבה שהיא. ל-Aasraw אין כל זיקה או קשר, משתמע או אחר, עם רופא זה. מטרת ציטוט הרופא הזה היא להכיר, להכיר ולשבח את עבודת המחקר והפיתוח הממצה שנעשתה על ידי המדענים העובדים על חומר זה.

התייחסות

[1] MC Walker, JW Sander. קשיים באקסטרפולציה מנתוני ניסויים קליניים לפרקטיקה קלינית: המקרה של תרופות אנטי אפילפטיות. נוירולוגיה, 49 (1997), עמ' 333-337

[2] MJ Field, RJ Oles, L. Singh. pregabalin עשוי לייצג סוג חדש של תרופות חרדה עם קשת רחבה של פעילות. Br J Pharmacol, 132 (2001), עמ' 1-4

[3] Hong JS, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. (מרץ 2022). "גבפנטין ופרגבלין בהפרעה דו-קוטבית, מצבי חרדה ונדודי שינה: סקירה שיטתית, מטה-אנליזה והיגיון". פסיכיאטריה מולקולרית. 27 (3): 1339–1349.

[4] Freynhagen R, Baron R, Kawaguchi Y, Malik RA, Martire DL, Parsons B, et al. (ינואר 2021). "פרגבלין לכאב נוירופטי במסגרות טיפול ראשוני: המלצות למינון וטיטרציה". רפואה לתואר שני. אינפורמה UK Limited. 133 (1): 1–9.

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